Part 2

SECTION 9. Physical and chemical properties

Physical State Crystal

Appearance Silvery-grey (Colorful surface due to its oxidize compounds)

Odor Odorless

pH No information available

Relative density (Water = 1) Approx. 10 - 11

Melting Point/Range 271 °C / 519.8 °F

Boiling Point/Range 1500 °C / 2732 °F

Flash Point No information available

Evaporation Rate Not applicable

Flammability (solid,gas) No information available

Flammability or explosive limits

Upper .00%

Lower 4.00%

Vapor Pressure 1 hPa @ 840 °C

Vapor Density Not applicable

Volatility Not applicable

Solubility Insoluble in water

Partition coefficient; n-octanol/water No data available

Autoignition Temperature

Decomposition Temperature No information available

Viscosity Not applicable

Molecular Formula Bi

Molecular Weight 208.98

Section 10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions.

Conditions to Avoid Avoid dust formation. Keep away from open flames, hot surfaces.

Incompatible products.

Incompatible Material Acids, Strong oxidizing agents, Halogens

Hazardous Decomposition Products None under normal use conditions

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

SECTION 11. TOXICOLOGICAL INFORMATION

Oral exposure:

A) MANAGEMENT OF MILD TOXICITY: Treat nausea and vomiting with antiemetics and fluids.

B) MANAGEMENT OF SEVERE TOXICITY: Severe toxicity is rare after acute ingestion.

C) PITFALLS:

Making the diagnosis of bismuth toxicity can be difficult without a clear history of exposure.

D) PHARMACOKINETICS

Only approximately 0.2% of orally administered bismuth is absorbed systemically from the gastrointestinal tract. The time to peak concentration is typically within one hour. The volume of distribution is unknown. The distribution half-life is approximately 1 to 4 hours, and the elimination half-life is 5 to 11 days. Urinary bismuth is detectable 3 months after the last dose.

Range of Toxicity:

A) TOXICITY:

Blood levels less than 5 mcg/dL are rarely associated with symptoms.

PEDIATRIC:

Acute toxic symptoms have occurred with as little as 5.2 mg IM over 26 hours in a 21-month-old to 30 g over 8 days in a 7.5-year-old. A 17-year-old developed acute renal failure but recovered after ingesting 7.5 g bismuth subcitrate.

B) THERAPEUTIC DOSE:

BISMUTH SUBSALICYLATE: 12 yrs and older: 524 mg orally every 0.5 to 1 hour, up to a maximum of 8

doses/day (4192 mg/day).

Acute:

Skin/Eye: Contact with dust or fume may cause local irritation but would not cause tissue damage. This material is not absorbed through the skin.

Inhalation: Inhalation of dust or fume may irritate the upper respiratory tract. Symptoms may include coughing, sneezing and/or shortness of breath. Intense exposure to dust or fume may cause headache, nausea, vomiting, abdominal spasms, fatigue, sleep disturbances, weight loss, anemia, and pain in legs, arms, and joints.

Ingestion: Symptoms due to ingestion of lead dust or fume would be similar to those from inhalation including nausea, vomiting, weakness, diarrhea, ulcerative stomatitis, pyorrhea, swelling of the buccal membranes, and increased salivation. Other health effects such as metallic taste in the mouth and constipation or bloody diarrhea might also be expected to occur.

SECTION 12. ECOLOGICAL INFORMATION

Ecotoxicity Do not empty into drains. .

Persistence and Degradability Insoluble in water

Bioaccumulation/ Accumulation No information available.

Mobility Is not likely mobile in the environment due its low water solubility.

Section 13. Disposal considerations

Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as

hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.

SECTION 14. TRANSPORT INFORMATION

DOT

UN-No UN3089

Proper Shipping Name Metal powder, flammable, n.o.s

Hazard Class 4.1

Packing Group II

TDG

UN-No UN3089

Proper Shipping Name METAL POWDER, FLAMMABLE, N.O.S.

Hazard Class 4.1

Packing Group II

IATA

UN-No UN3089

Proper Shipping Name METAL POWDER, FLAMMABLE, N.O.S.

Hazard Class 4.1

Packing Group II

IMDG/IMO

UN-No UN3089

Proper Shipping Name METAL POWDER, FLAMMABLE, N.O.S.

Hazard Class 4.1

Packing Group II

Section 15. Regulatory information

International inventories: (X indicates listed; else indicates no information available)

Component	TSCA	DSL	NDSL	EINECS	ELINCS	NLP	PICCS	ENCS	AICS	IECSC	KECL
Bismuth powder	X	X	-	231-177-4	-		X	-	X	X	X

Relevant regulations of supervising the material:

GB/T 16483-2008: Material Safety Data Sheet – Contents and the order of sections.

67/548/EEC: European REACH (The classification and identification of chemical hazards.)

Chemical safety assessment

For this product, a chemical safety assessment was not carried out.

SECTION 16. Other information

The information in this Safety Data Sheet is based on the following references:

Chemical Book. https://www.chemicalbook.com/. Accessed on May 20^th, 2019.
TOXNET, U.S. National Liabiray of Medicine. Accessed on May 20^th, 2019.
National Institution of Standards and Technology. https://www.nist.gov/. Accessed on May 20^th, 2019.
CCOHS, RTECS. http://ccinfoweb.ccohs.ca/rtecs/search.html. Accessed on May 20^th, 2019.
https://www.chemsafetypro.com/Topics/GHS/GHS_hazard_class.html. Accessed onMay 20^th, 2019.
S. Department of Labor. https://web.archive.org/web/20070702005153/http://www.osha.gov/dsg/hazcom/ghs.html#3.0. Accessed on May 20^th, 2019.
CDH FineChemical. http://cdhfinechemical.lookchem.com/. Accessed on May 20^th, 2019.
Angstrom Sciences, Inc. 40 South Linden Street, Duquesne, PA 15110. Safety Data Sheet of Bismuth. (2015)
ESPI Metals. 1050 Benson Way, Ashland, OR 97520. Safety Data Sheet of Bismuth. (2015)
ThermoFisher SCIENTIFIC. Fair Lawn, NJ 07410. Safety Data Sheet of Bismuth. (2008)
ThermoFisher SCIENTIFIC. Fair Lawn, NJ 07410. http://www.finarchemicals.com/msds/. Index of msds. Accessed on May 20^th, 2019.
Acros Organics BVBA, Janssen Pharmaceuticalaan 3a, 2440 Geel, Belgium. MSDS#96777. (2009)
Teck Metals Ltd. Suite 3300-550 Burrard Street, Vancouver, British Columbia. Safety Data Sheet of Bismuth. (2015)

Notice to Readers

The information contained in this document is based on the state of our knowledge at the time of publication and is believed to be correct, but does not purport to be all inclusive and shall be used only as a guide. All the data and information provided in this Safety Data Sheet represents a compilation of data drawn directly from various sources available to us. Our group makes no representation or guarantee as to the suitability of this information to a particular application of a substance covered in the Safety Data Sheet.

GLOSSARY:

CAS - Chemical Abstracts Service HMIS - Hazardous Material Information System

RTECS - Registry of Toxic Effects of Chemical Substances TSCA - Toxic Substances Control Act

NFPA - National Fire Protection Association SCBA - Self-contained breathing apparatus

OSHA - Occupational Safety and Health Administration PEL – Permissible Exposure Limit

NIOSH - National Institute for Occupational Safety and Health REL – Recommended Exposure Limit

ACGIH - American Conference of Governmental Industrial Hygienists TLV – Threshold Limit Value

DOT - US Department of Transportation TDG – Dangerous Goods

IATA - The International Air Transport Association IMDG/IMO - International Maritime Dangerous Goods

GHS - Globally Harmonized System of Classification and Labeling of Chemicals

CLP – Guidance on Labeling and Packaging in accordance with Regulations (EC)

EC - European INventory of Existing commercial Chemical Substances

Relevant Links

Relevant Links

Safety Data Sheet of Bismuth

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